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目的探讨盐酸氨溴索静注联合鼻塞式持续正压通气(CPAP)对新生儿肺炎血气指标的影响。方法选取2011年1月-2015年1月该院收治的新生儿肺炎患儿80例为研究对象,随机分为对照组和联合组,每组各40例。对照组患儿采用常规治疗加鼻塞式CPAP,联合组患儿在对照组的基础上增加使用盐酸氨溴索,比较两组患儿血气指标和临床疗效。结果联合组患儿治疗24h后PaO2、氧合指数明显上升,PaCO2明显下降(P<0.05);联合组患儿临床有效率高于对照组,差异有统计学意义(P<0.05);联合组鼻塞式CPAP治疗时间、肺部啰音消失时间、住院天数均短于对照组,差异有统计学意义(P<0.05)。结论盐酸氨溴索静注联合鼻塞式CPAP可以改善新生儿肺炎患儿的血气指标,临床效果好。
Objective To investigate the effect of ambroxol hydrochloride combined with nasal continuous positive pressure ventilation (CPAP) on neonatal pneumonia. Methods Eighty children with neonatal pneumonia admitted in our hospital from January 2011 to January 2015 were selected as study subjects and randomly divided into control group and combination group with 40 cases in each group. Children in the control group received routine therapy plus nasal CPAP, and ambroxol hydrochloride was added to the combination group on the basis of the control group. Blood gas indexes and clinical effects were compared between the two groups. Results After treatment for 24 hours, the PaO2 and PaO2 in the combined group were significantly increased (P <0.05). The clinical effective rate in the combined group was significantly higher than that in the control group (P <0.05) Nasal CPAP treatment time, pulmonary rales disappeared time, hospitalization days were shorter than the control group, the difference was statistically significant (P <0.05). Conclusions Ambroxol hydrochloride intravenous infusion combined with nasal CPAP can improve neonatal pneumonia in children with blood gas index, clinical effect is good.