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目的探讨非小细胞肺癌患者血浆纤维蛋白原(FIB)、血清高敏C反应蛋白(hs-CRP)在化疗前后变化。方法测定68例非小细胞肺癌患者的血浆FIB、血清hs-CRP水平在化疗前后的变化,并和健康对照组进行比较。结果非小细胞肺癌组hs-CRP、FIB的水平明显高于对照组(P<0.05);对非小细胞肺癌患者化疗有效者hs-CRP、FIB水平明显降低。结论血浆FIB、血清hs-CRP检测对非小细胞肺癌患者病情判定及疗效监测有重要临床意义。
Objective To investigate the changes of plasma fibrinogen (FIB) and serum high-sensitivity C-reactive protein (hs-CRP) before and after chemotherapy in patients with non-small cell lung cancer. Methods The changes of plasma FIB and serum hs-CRP levels in 68 patients with non-small cell lung cancer before and after chemotherapy were measured and compared with those in healthy controls. Results The levels of hs-CRP and FIB in non-small cell lung cancer group were significantly higher than those in control group (P <0.05). The hs-CRP and FIB levels in non-small cell lung cancer patients were significantly decreased after chemotherapy. Conclusion The detection of plasma FIB and serum hs-CRP has important clinical significance in the judgment of disease status and monitoring of the curative effect in patients with non-small cell lung cancer.