本文报道亚氨二羧酸二乙酯(1)在固/液相转移催化下,直接进行N-烷基化反应的方法。作用物(1)在DMF中经碳酸钾处理,然后使之与种种烷基化试剂,如:氯乙酸甲酯、氯乙腈、1,3二溴丙烷,+x,x′二氯对二甲苯等,按方法A,B或C反应。生成的N-烷基化产物均经过元素分析和光谱鉴定。 This paper reports the direct N-alkylation of diethyl iminodicarboxylate (1) under solid / liquid phase transfer catalysis. The substrate (1) is treated with potassium carbonate in DMF and then reacted with various alkylating reagents such as methyl chloroacetate, chloroacetonitrile, 1,3 dibromopropane, + x, x’dichloro-p-xylene Etc., according to the method A, B or C reaction. The resulting N-alkylated products were subjected to elemental analysis and spectral identification.