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目的观察国产表阿霉素治疗非霍奇金淋巴瘤的疗效和毒副反应。方法治疗组37例采用环磷酰胺(CTX)750 mg/(m2.d),静脉滴注,d1;国产表阿素(EPI)70 mg/(m2.d),静脉推注,d1;长春新碱(VCR)1.4 mg/(m2.d),静脉推注,d1;强的松(Pred)60 mg/(m2.d),口服,d1~5。每21 d为一个疗程,每例患者至少接受4个周期的化疗。对照组以进口表阿霉素替代国产表阿霉素,治疗非霍奇淋巴瘤38例,进行随机对照,观察两组的疗效及毒副反应。结果国产表阿霉素为主的方案组,完全缓解率为43.2%(16/37),部分缓解率为37.8%(14/37),总有效率为81.1%。与进口表阿霉素为主的对照组比较,疗效相似,差异无显著性(P>0.05)。两组毒副反应主要为Ⅰ~Ⅱ度,治疗组与对照组白细胞减少发生率分别为59.5%和60.5%;恶心呕吐发生率分别为67.6%和68.4%;心脏毒性轻微,发生率分别为8.1%和7.9%;脱发发生率分别为94.6%和94.7%,对肝肾功能影响均较轻微。结论国产表阿霉素治疗非霍奇金淋巴瘤的疗效和毒副反应与进口表阿霉素相似,值得临床应用。
Objective To observe the efficacy and side effects of domestic epirubicin in the treatment of non-Hodgkin’s lymphoma. Methods Thirty-seven patients in the treatment group were treated with cyclophosphamide (CTX) 750 mg / (m2.d), intravenous drip, d1; EPI 70 mg / (m2.d), intravenous injection, d1; Changchun VCR 1.4 mg / (m2.d), intravenous bolus, d1 prednisone (Pred) 60 mg / (m2.d) orally, d1 to 5. Every 21 days for a course of treatment, each patient received at least 4 cycles of chemotherapy. Control group imported epirubicin to replace domestic epirubicin, 38 cases of non-Hodgkin’s lymphoma were randomized to observe the curative effect and side effects of the two groups. The results of the domestic epirubicin-based program group, the complete remission rate was 43.2% (16/37), the partial response rate was 37.8% (14/37), the total effective rate was 81.1%. Compared with the imported epirubicin-based control group, the curative effect was similar with no significant difference (P> 0.05). The two groups of side effects mainly Ⅰ ~ Ⅱ degrees, the incidence of leukopenia in the treatment group and the control group were 59.5% and 60.5% respectively; the incidence of nausea and vomiting was 67.6% and 68.4% respectively; the cardiotoxicity was mild and the incidence rates were 8.1 % And 7.9% respectively. The incidence of hair loss was 94.6% and 94.7% respectively, which had a slight effect on liver and kidney function. Conclusion The efficacy and toxicity of domestic epirubicin in the treatment of non-Hodgkin’s lymphoma is similar to that of imported epirubicin, which is worthy of clinical application.