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四氢香叶醇（THG）是一种开环单萜，通过格林那达试剂，使四氢香叶醇和环氧乙烷反应，合成出一种新的醇类衍生物：5，9－二甲基－1－癸醇（DIMDOL）。使用双室扩散池装置，应用体外渗透技术，研究了DIMDOL对5－氟脲嘧啶和盐酸曲马多穿透离体小鼠皮肤的促进作用，以阿佐恩（Azone）和THG作为对照促进剂进行比较。DIMDOL对5－氟脲嘧啶和盐酸曲马多的渗透率分别增加18.60和73.19倍，滞后时间分别为3.35和1．20小时，分配系数和扩散系数也同时增加、结果表明DIMDOL主要影响角质层，干扰了其中的类脂层和角蛋白层。
Tetrahydropyranol (THG) is a ring-opened monoterpene, through the Grenada reagent, so tetrahydro geraniol and ethylene oxide reaction to synthesize a new alcohol derivatives: 5,9-bis Methyl-1-decanol (DIMDOL). The use of dual-cell diffusion cell device, the use of in vitro osmotic technology, studied DIMDOL on 5-fluorouracil and tramadol hydrochloride penetration through the skin of mice in vitro, with Azone (Azone) and THG as a control accelerator Compare DIMDOL increased the permeabilities of 5-fluorouracil and tramadol hydrochloride by 18.60 and 73.19 times, respectively, with hysteresis times of 3.35 and 1.20 hours, respectively. The partition coefficient and diffusion coefficient also increased at the same time. The results showed that DIMDOL mainly affected the stratum corneum, Interfere with the lipid layer and the keratin layer.