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目的:探讨卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)的发病机制、临床特征、治疗及预防措施。方法:回顾分析2004年2月至2009年3月在本院住院治疗的72例中重度OHSS患者临床资料,将患者分为早发组和迟发组,比较两组患者的临床特征和实验室资料。结果:早发组患者为42例(58.3%),迟发组为30例(41.6%)。迟发组胸腹水、肝肾功能不全、重度OHSS发生率和妊娠率均高于早发组(P<0.05),迟发组患者注射HCG当日的成熟卵泡数高于早发组(P<0.05),但雌二醇水平(3673.44±472.31)pg/mL低于早发组(P<0.05)。结论:早发组和迟发组患者的临床特征有较大的差异,掌握两种分型的发病特点,对于中重度OHSS的预防和治疗具有重要意义。
Objective: To investigate the pathogenesis, clinical characteristics, treatment and preventive measures of ovarian hyperstimulation syndrome (OHSS). Methods: The clinical data of 72 patients with moderate-to-severe OHSS hospitalized in our hospital from February 2004 to March 2009 were retrospectively analyzed. The patients were divided into early-onset group and late-onset group. The clinical characteristics and laboratory of the two groups were compared data. Results: 42 cases (58.3%) in the early onset group and 30 cases (41.6%) in the late onset group. The incidence of hydrothorax, liver and renal dysfunction, severe OHSS and pregnancy rate in late onset group were higher than those in early onset group (P <0.05), and the number of mature follicles in late onset group was higher than that in early onset group (P <0.05) ), But the estradiol level (3673.44 ± 472.31) pg / mL was lower than that of the early onset group (P <0.05). Conclusion: The clinical features of early-onset and late-onset patients are quite different. It is of great significance to master the characteristics of the two types of disease for the prevention and treatment of moderate-severe OHSS.