Ｌｅｐｔｉｎ 与胰腺、肾上腺、性腺、甲状腺等多个内分泌腺密切相关。Ｌｅｐｔｉｎ 是胰腺胰岛素分泌的抑制剂，与体内脂肪含量、空腹血浆胰岛素水平正相关，而胰岛素可调节Ｌｅｐｔｉｎ 的分泌。糖皮质激素是Ｌｅｐｔｉｎ 分泌的强烈刺激物，中枢性给予Ｌｅｐｔｉｎ 可刺激肾上腺皮质功能，而外周性应用Ｌｅｐｔｉｎ 则显著抑制皮质激素的分泌。此外，Ｌｅｐｔｉｎ 可促进生育和生殖，对性腺可能发挥直接的抑制作用。Ｌｅｐｔｉｎ 与甲状腺功能之间也有一定的联系。 Leptin and the pancreas, adrenal, gonads, thyroid and other endocrine glands are closely related. Leptin is an inhibitor of pancreatic insulin secretion with a positive correlation with body fat content and fasting plasma insulin levels, while insulin regulates Leptin secretion. Glucocorticoids are a strong stimulant of Leptin secretion. Central Leptin stimulates adrenocortical function, while peripheral administration of Leptin significantly inhibits the secretion of corticosteroids. In addition, Leptin can promote fertility and reproduction, may have a direct inhibitory effect on the gonads. There is also a link between Leptin and thyroid function.