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用抗HBsAg免疫吸附柱从污水中分离抗原性与HBsAg相同的物质,并经放射免疫扩散自显影术鉴定予以肯定。电镜观察抗原阳性水中有直径22毫微米左右的球状颗粒。水源污染情况与用水人群血清HBsAg阳性率有正相关性。用改进的IAHA及PHA对某肝癌高发地区的自然人群进行了HBsAg及其抗体的检测。并与其邻近的某地区的资料作了比较,表明HBsAg阳性率与肝癌发病率呈正相关的关系。对某肝癌高发地区的肝癌高发公社与低发公社的HBsAg阳性率和肝癌发病率作了调查,数次调查结果不一致,对此进行了讨论。用普通对流免疫电泳检测HBsAg的阳性率约为IAHA检测的三分之一,表明用普通对流免疫电泳进行普查,将有三分之二的HBsAg携带者被漏检。
The antigens of HBsAg were separated from the sewage by anti-HBsAg immuno-adsorption column and confirmed by radioimmunoassay and autoradiography. Electron microscopy antigen-positive water has a diameter of about 22 nm spherical particles. There was a positive correlation between the water pollution and the serum HBsAg positive rate in water consuming population. HBsAg and its antibodies were detected in the natural population of a high incidence of liver cancer with modified IAHA and PHA. And compared with the data of a nearby area, indicating that the positive rate of HBsAg and the incidence of liver cancer was positively correlated. The prevalence of HBsAg and the incidence of liver cancer in HCC high-risk communes and low-commune communes in a high incidence area of liver cancer were investigated. The results of several surveys were inconsistent and discussed. The positive rate of HBsAg detected by conventional convective immuno-electrophoresis was about one-third of that of IAHA, indicating that two-thirds of HBsAg carriers were undetected by ordinary convective immunoelectrophoresis.