实验室前期合成的2位含有酯基的1,5-苯并硫氮杂卓化合物具有很好的抑菌活性,通过一系列反应,在其中引入了1,2,4-噁二唑环,得到一系列新的噁二唑并[5,4-d]1,5-苯并硫氮杂卓衍生物,考察了底物中亚胺双键的消失,噁二唑环的引入对抑菌活性的影响。新化合物的结构经IR、1HNMR、MS和元素分析确证,对新化合物的抑菌活性做了初步的测试。 The 1,5-benzothiazepine compound with ester group synthesized in the laboratory at the early stage has good antibacterial activity. Through a series of reactions, 1,2,4-oxadiazole ring was introduced, A series of novel oxadiazolo [5,4-d] 1,5-benzothiazepine derivatives were obtained. The disappearance of the imine double bond in the substrate was investigated. Effect of activity. The structures of the new compounds were confirmed by IR, 1HNMR, MS and elemental analysis. The antibacterial activities of the new compounds were tested.