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脊髓损伤动物模型有重力坠落法模型、挫伤模型、撕裂伤模型、动脉夹压力模型、脊髓缺血损伤模型及化学药物介导的脊髓损伤模型等。其中,重力坠落法和挫伤模型比较常用,其操作简单,可调控性及可重复性良好,但二者都忽略了临床脊髓损伤机制中持续性挤压的问题;动脉夹压力模型虽然更接近临床脊髓损伤机制,但其在可调控性及重复性方面尚难以达到一致认可。撕裂伤模型是组织工程学及神经干细胞移植修复脊髓研究的良好模型,经过发展已具备良好的可调控性及可重复性。脊髓缺血损伤模型和化学药物介导的SCI模型为细致研究脊髓损伤后神经病理生理学变化提供了良好的平台,但操作技术相对复杂。
Spinal cord injury animal model gravity fall model, contusion model, laceration model, arterial clamping pressure model, spinal cord injury model and chemical drug-mediated spinal cord injury model. Among them, the gravity fall method and the contusion model are more commonly used, and their operation is simple, and the controllability and repeatability are good. However, both of them ignore the problem of persistent extrusion in the clinical spinal cord injury mechanism. Although the arterial compression model is closer to clinical Spinal cord injury mechanism, but its regulative and repeatability is still difficult to reach consensus. Laryngeal injury model is a good model for tissue engineering and neural stem cell transplantation to repair spinal cord research, which has been well developed and reproducible. Spinal cord ischemia injury model and chemical drug-mediated SCI model provide a good platform for detailed study of neuropathological changes after spinal cord injury, but the operation technique is relatively complicated.