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检测54例2型DPN患者与30例正常对照组血清中丙二醛(MDA)与超氧化物歧化酶(SOD)含量与活性;随机分为GSH组和CON对照组。GSH组予谷胱甘肽1.8g/d,静点14d,CON组常规给予B族维生素治疗,分别检测治疗前后MDA、SOD及下肢感觉神经传导速度(SCV),同时用全自动生化分析仪测,TH、HDL,HbA1c,ALB,分析对MDA、SOD、SCV的影响。结果HbA1c、TG、HDL对MDA均有相关性,其中HbA1c影响较大(R=0.0718);HbA1c对SOD也有一定相关性(R=0.0443)。在糖尿病神经损伤修复方面的相关因素中,病程、HbA1c、HDL、ALB对SCV均有相关性,高密度脂蛋白对SCV的影响最大(R=0.0796);病程对SCV的影响最小(R=0.0447)差别有统计学意义。结论DPN患者存在着严重的氧化应激状态,这可能与HbA1c、血脂相关。同时,HbA1c、血脂、ALB以及病程等因素又进一步加剧体内氧化应激程度,加重了神经病变的发展。
Serum levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in 54 patients with type 2 DPN and 30 normal controls were measured. The levels of MDA and SOD were measured and randomly divided into GSH group and CON control group. GSH group was given glutathione 1.8g / d for 14 days, and CON group was given B vitamins routinely to detect MDA, SOD and sensory nerve conduction velocity (SCV) before and after treatment. Meanwhile, , TH, HDL, HbA1c and ALB, and analyzed the effects on MDA, SOD and SCV. Results HbA1c, TG and HDL were correlated with MDA, of which HbA1c was more affected (R = 0.0718). HbA1c was also correlated with SOD (R = 0.0443). HbA1c, HDL and ALB were associated with SCV in all the factors related to the repair of diabetic nerve injury. High-density lipoprotein (HDL) had the strongest effect on SCV (R = 0.0796); duration had the least effect on SCV (R = 0.0447 ) The difference was statistically significant. Conclusion There is a serious oxidative stress in DPN patients, which may be related to HbA1c and lipids. At the same time, factors such as HbA1c, blood lipid, ALB, and course of disease further exacerbated the degree of oxidative stress in vivo, aggravating the development of neuropathy.