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目的:评价国产表阿霉素治疗多种恶性肿瘤的疗效和毒性。方法:选择1998年4月至10月乳腺癌、非小细胞肺癌和恶性淋巴瘤等不同恶性肿瘤患者60例,对应用国产表阿霉素为主的与进口表阿霉素为主的化疗方案的临床疗效、毒副反应进行观察。结果:可评价疗效和毒性的病人60例,国产组的完全缓解率为23.33%(7/30),部分缓解率为40.00%(12/30),总有效率为63.33%,其中恶性淋巴瘤疗效最好,有效率为84.61%。两组总有效率及各类肿瘤的有效率相比结果相似(P>0.05)。两组的毒性反应均为Ⅰ～Ⅱ度白细胞减少,Ⅰ～Ⅱ度恶心呕吐及不同程度的脱发(P>0.05)。结论:国产表阿霉素治疗恶性肿瘤的疗效、毒副反应与进口表阿霉素相似。
Objective: To evaluate the efficacy and toxicity of domestic epirubicin in the treatment of various malignancies. Methods: Sixty patients with different malignant tumors, including breast cancer, non-small cell lung cancer and malignant lymphoma, were selected from April 1998 to October 1998. The chemotherapy regimens mainly on domestic epirubicin and imported epirubicin The clinical efficacy of toxic and side effects observed. Results: 60 patients could evaluate the curative effect and toxicity, the complete remission rate was 23.33% (7/30) in domestic group, the partial remission rate was 40.00% (12/30), the total effective rate was 63.33%, of which malignant lymphoma The best effect, effective rate was 84.61%. The total effective rate of the two groups and the efficiency of various types of tumors were similar (P> 0.05). The toxicity of the two groups were Ⅰ ~ Ⅱ leucopenia, Ⅰ ~ Ⅱ degree nausea and vomiting and varying degrees of hair loss (P> 0.05). Conclusion: The efficacy of domestic epirubicin in treating malignant tumors is similar to that of imported epirubicin.