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环氧化酶(cyclooxygenase,cox)-2与 cox-1于同工酶,是前列腺素(PG)合成过程中的重要限速酶,在结肠癌、食管癌、肺癌、胃癌、膀胱癌、宫颈癌等多种上皮肿瘤中都有 COX-2表达的异常增高。子宫内膜癌是妇科第2位恶性肿瘤,严重危害中老年妇女的生命健康,其发展呈年轻化,并表现为时间依赖式发展,从子宫内膜复杂型增生到非典型增生再到浸润性癌。早期肿瘤仍然存在一定的复发和侵袭的特征,严重影响预后。
Cyclooxygenase (COX) -2 and cox-1 are isoenzymes, which are important rate-limiting enzymes in the synthesis of prostaglandin (PG). They are widely used in colon cancer, esophageal cancer, lung cancer, gastric cancer, bladder cancer, Cancer and other epithelial tumors have an abnormal increase in COX-2 expression. Endometrial cancer is the second malignant tumor of gynecology, which seriously endangers the life and health of middle-aged and elderly women. The development of the disease is younger and shows a time-dependent development. From endometrial hyperplasia to atypical hyperplasia to infiltration cancer. Early tumors still have some characteristics of recurrence and invasion, seriously affecting the prognosis.