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当组织细胞对热或其它刺激反应时，均被诱导增加ＨＳＰｓ合成。本研究将８只雄性大鼠随机分为四组，分别为对照组、高温组、ＣＯ组、高温＋ＣＯ组。在送氧式高温与毒物联合作用装置中染毒１ｈ，在室温下恢复１ｈ后，测定其肛温、ＨｂＣＯ。断头处死，取其肝脏分析ＨＳＰ７０ｍＲＮＡ和ＨＳＰ７０。结果如下：（１）与对照组相比，高温组、高温＋ＣＯ组大鼠肛温均升高３．０℃以上，ＣＯ组及高温＋ＣＯ组大鼠ＨｂＣＯ含量均达３０％以上，这说明受热及染毒后动物的体温及ＨｂＣＯ含量均符合本实验要求。（２）结果显示，对照组仅有少量ＨＳＰ７０ｍＲＮＡ，与之相比，ＣＯ组有所增加，高温组增加明显，而高温＋ＣＯ组增加更为明显，表现为协同作用。ＨＳＰ７０合成也与ＨＳＰ７０ｍＲＮＡ结果一致。
Tissue cells are induced to increase HSPs synthesis when they respond to heat or other stimuli. In this study, eight male rats were randomly divided into four groups, namely, control group, high temperature group, CO group, high temperature + CO group. In the oxygen-type high temperature and toxic joint action device exposure 1h, after recovery at room temperature for 1h, the rectal temperature was measured, HbCO. The decapitated sacrifice, take its liver analysis HSP70mRNA and HSP70. The results were as follows: (1) Compared with the control group, the rectal temperature of rats in high temperature group and high temperature + CO group increased by more than 3.0 ℃, and the HbCO content in CO group and hyperthermia + CO group reached more than 30% Toxic animals after the body temperature and HbCO content are in line with the requirements of this experiment. (2) The results showed that there was only a small amount of HSP70mRNA in the control group. Compared with the control group, the CO group increased, the hyperthermia group increased significantly, and the hyperthermia + CO group increased more obviously, showing a synergistic effect. HSP70 synthesis is also consistent with HSP70 mRNA results.