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白细胞介素 12 (IL - 12 )在诱导T细胞向Th1类细胞分化过程中起关键性作用 ,可选择性抑制自身免疫性抗体分泌细胞B1细胞的增殖 .对系统性红斑狼疮 (SLE)患者的多种体外研究均说明 :IL - 12分泌减少在SLE患者细胞因子分泌异常及多克隆自身抗体产生中起重要作用
Interleukin 12 (IL - 12) plays a key role in inducing T cells to differentiate into Th1 type cells and selectively inhibits the proliferation of B1 cells in autoimmune antibody - secreting cells. In patients with systemic lupus erythematosus (SLE) Various in vitro studies have demonstrated that decreased IL - 12 secretion plays an important role in the abnormal secretion of cytokines and polyclonal autoantibodies in patients with SLE