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新生儿全身性细菌感染(败血症和脑膜炎)是常见的,预后仍较差。急性期反应物尤以血中纤维蛋白原,CRP 和血清类粘蛋白已经被利用作为感染的指标,然而,却不可避免地失败了。随Drew 之后,我们试用C3d 作为新生儿期感染的诊断指标。C3d 是C3的主要代谢产物,第三个补体成份,在通过旁路激活免疫反应经路中占有中心地位。所以,无论什么时候,只要抗原伴复合物形成,或细菌内毒素激活更迭的免疫径路时,C3d 就可在血循环中出现。材料和方法研究本院ICU 被怀疑感染的新生儿,做血离子、钙、糖、白蛋白、CRP、纤维蛋白原、C3d、血细胞计数、凝血时、血培养、咽部病原
Neonatal systemic bacterial infections (sepsis and meningitis) are common and prognosis is poor. Acute phase reactants, especially blood fibrinogen, CRP and serum mucins have been used as an indicator of infection, however, but inevitably failed. After Drew, we tried C3d as a diagnostic indicator of neonatal infection. C3d is the major metabolite of C3, the third complement component that plays a central role in the pathway of activation of the immune response via the bypass. Therefore, C3d can appear in the blood circulation whenever antigenic complex is formed, or when bacterial endotoxin activates alternate immune pathways. MATERIALS AND METHODS Study of newborns suspected to be infected with ICU in our hospital were performed blood plasma, calcium, sugar, albumin, CRP, fibrinogen, C3d, blood cell count, blood coagulation, blood culture, pharyngeal pathogen