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目的研究理肺散原植物攀援耳草Hedyotis scandens的化学成分。方法采用硅胶、ODS、Sephadex LH-20及RP-HPLC等色谱技术对理肺散的化学成分进行分离纯化,根据理化性质及波谱数据鉴定化合物结构。结果从理肺散的醋酸乙酯部位分离得到了13个化合物,分别鉴定为齐墩果酸(1)、2α,3α,24-三羟基-12-烯-28-齐墩果酸(2)、2α,3β,24-三羟基-12-烯-28-齐墩果酸(3)、2α,3β-二羟基-12-烯-28-乌苏酸(4)、2α,3β,19α-三羟基-12-烯-28-乌苏酸(5)、白桦酸(6)、山柰酚-3-O-β-D-葡萄糖苷(7)、槲皮素(8)、芹菜素(9)、芹菜素-7-O-β-D-葡萄糖苷(10)、木犀草素(11)、木犀草素-7-O-β-D-葡萄糖苷(12)和胡萝卜苷(13)。结论化合物1～13均为首次从该植物中分离得到。
Objective To study the chemical constituents of the Hedyotis scandens from Lophnia magna. Methods Silica gel, ODS, Sephadex LH-20 and RP-HPLC and other chromatographic techniques were used to separate and purify the chemical components of Li-lung powder. The structures of the compounds were identified by physicochemical properties and spectral data. Results Thirteen compounds were isolated from the ethyl acetate fraction of Li-lung San and identified as oleanolic acid (1), 2α, 3α, 24-trihydroxy-12-en-28- (3), 2α, 3β-dihydroxy-12-ene-28-ursuic acid (4), 2α, 3β, 24α-trihydroxy- (5), betulinic acid (6), kaempferol-3-O-β-D-glucoside (7), quercetin (8), apigenin 9), apigenin-7-O-β-D-glucoside (10), luteolin (11), luteolin-7-O- β-D-glucoside (12) and daucosterol (13) . Conclusion Compounds 1 ~ 13 were isolated from this plant for the first time.