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目的探讨辛伐他汀对蛛网膜下腔出血治疗作用。方法将连平县人民医院2003年3月～2005年3月128例蛛网膜下腔出血的住院患者随机分为2组(所有病例均给以常规治疗并静脉注射尼膜地平):治疗组(口服辛伐他汀组)64例,给予口服或者鼻饲辛伐他汀20mg,每日2次;对照组(常规治疗组)64例,给予安慰剂口服,每日2次。14d后对患者进行神经功能缺损评分并行头颅CT等检查。结果14d的治疗后治疗组较对照组神经功能缺损评分明显降低,二者比较差异有显著性意义(P<0.05)。脑血管痉挛的发生率:治疗组为4例,对照组11例,二者比较有显著性意义(P<0.01)。结论口服辛伐他汀能明显改善蛛网膜下腔出血后神经功能缺损评分。
Objective To investigate the therapeutic effect of simvastatin on subarachnoid hemorrhage. Methods A total of 128 inpatients with subarachnoid hemorrhage from March 2003 to March 2005 in Lianping County People’s Hospital were randomly divided into 2 groups (all cases were given routine treatment and intravenous nimotop peace): treatment group ( Oral Simvastatin group), 64 cases were given oral or nasal simvastatin 20mg twice a day; control group (conventional treatment group) 64 cases were given placebo orally twice daily. 14d after neurological deficits in patients with head CT and other tests. Results After 14 days of treatment, the scores of neurological deficits in the treatment group were significantly lower than those in the control group, with significant difference between the two groups (P <0.05). The incidence of cerebral vasospasm: the treatment group was 4 cases, the control group, 11 cases, the two were statistically significant (P <0.01). Conclusion Oral simvastatin can significantly improve the neurological deficit score after subarachnoid hemorrhage.