论文部分内容阅读
目的探讨肺炎支原体(MP)感染与儿童哮喘(bronchial asthma in children)发病的关系。方法入选53例支气管哮喘患儿作为观察组,40例呼吸道感染患儿(包括肺炎及支气管炎)作为对照组,采用明胶颗粒凝集试验检测两组患儿血清肺炎支原体IgM(MP-IgM)抗体,同时采用ELISA法和血球分析仪常规法测定支气管哮喘患儿血清总IgE水平和外周血嗜酸粒细胞计数。结果 53例支气管哮喘患儿中,有26例血MP-IgM阳性,阳性率为49%;而40例对照组患儿中有7例血MP-IgM阳性,阳性率为17.5%,两组比较差异有统计学意义(P<0.01)。MP-IgM阳性的支气管哮喘患儿血清总IgE水平高于MP-IgM阴性的支气管哮喘患儿(t=3.369,P=0.002),MP-IgM阳性的支气管哮喘患儿嗜酸粒细胞计数(EOS)高于MP-IgM阴性的支气管哮喘患儿(t=8.548,P=0.001),两组比较,差异有统计学意义(P<0.01)。结论肺炎支原体感染与儿童哮喘有密切相关性。
Objective To investigate the relationship between Mycoplasma pneumoniae (MP) infection and the pathogenesis of bronchial asthma in children. Methods 53 children with bronchial asthma were selected as the observation group and 40 children with respiratory tract infection (including pneumonia and bronchitis) as the control group. Serum Mycoplasma pneumoniae IgM (MP-IgM) antibody was detected by gelatin particle agglutination test in two groups, Serum total IgE levels and peripheral blood eosinophil counts in children with bronchial asthma were determined by ELISA and routine hematology analyzer. Results Of the 53 children with bronchial asthma, 26 were positive for MP-IgM, and the positive rate was 49%. Seven of the 40 children in the control group were positive for MP-IgM, the positive rate was 17.5% The difference was statistically significant (P <0.01). Serum total IgE levels in children with MP-IgM-positive bronchial asthma were higher than those in children with bronchial asthma with MP-IgM negative (t = 3.369, P = 0.002), eosinophil counts in children with MP-IgM positive bronchial asthma ) Was higher than that of MP-IgM-negative asthmatic children (t = 8.548, P = 0.001). There was significant difference between the two groups (P <0.01). Conclusions Mycoplasma pneumoniae infection is closely related to childhood asthma.