本文采用药物致畸法研究了三种药物:敌枯双、环磷酰胺、亚硝酸钠对致乏库蚊染色体的细胞遗传学效应。结果表明:三种药物都能引起致乏库蚊染色体发生畸变,致畸效应依次为环磷酰胺>敌枯双>亚硝酸钠。畸变类型主要为染色单体畸变,以四辐体、环状体为主。本文还对药物浓度与致畸效应的关系以及 In this paper, drug-induced teratogenicity study of three drugs: Zuobu Shuang, cyclophosphamide, sodium nitrite on the Culex pipiens pallens chromosomal cytogenetic effect. The results showed that all the three drugs could cause the chromosome aberration of Culex pipiens pallens, the teratogenic effects were cyclophosphamide> Zuobuhuang> sodium nitrite. The main types of aberrations are chromatid aberrations, which are dominated by four radicles and rings. This article also examines the relationship between drug concentration and teratogenic effects as well