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从雷公藤 ( Tripterygium wilfordii Hook.f.)根皮的丙酮提取物中分得 11个化合物 ,经理化数据及光谱分析鉴定了它们的结构为 :雷公藤红素 ( Tripterine1) ,Polpunonic acid( 2 ) ,2 - Hydroxy- polpunonic acid( 3) ,2 ,3- Dihydroxy- friedel- 6,9( 11) - en-2 9- oic acid( 4 ) ,Demethylzeylasteral( 5) ,Orthosphenic acid( 6) ,萨拉子酸 ( Salaspermicacid7) ,Cangoronine( 8) ,3- Hydroxy- 2 - oxo- 3- fridelen- 2 0 α- carboxylic acid( 9) ,雷藤三萜酸 A( 3β,2 2 α- Dihydroxy- olean- 12 - en- 2 9- oic acid10 ) ,雷藤三萜酸 B( 3β,2 2 β- Dihydroxy-olean- 12 - en- 2 9- oic acid11)。 ( 3)为新化合物。初步药理结果显示 :化合物 ( 1) ,( 3) ,( 4 ) ,( 5) ,( 7)和 ( 8)有抑制免疫活性作用 ,化合物 ( 1) ,( 4 ) ,( 5)有抗菌作用 ,化合物 ( 1)对豚鼠肺 LTD4 有拮抗作用。
Twenty-one compounds were extracted from the acetone extract of Tripterygium wilfordii Hook.f. roots, and their structures were identified as: Tripterine1, Polpunonic acid(2). ,2- Hydroxy-polpunonic acid( 3) ,2 ,3- Dihydroxy- friedel- 6,9( 11)-en-2 9- oic acid( 4 ),Demethylzeylasteral( 5),Orthosphenic acid( 6),Sara Acids (Salaspermicacid7), Cangoronine (8), 3- Hydroxy- 2-oxo-3- fridelen- 2 0 α-carboxylic acid (9), Rhodamine A (3β, 2 2 α-Dihydroxy-olean- 12 - en- 2 9- oic acid10 ), Rhetacid 3 (3β, 2 2 β-Dihydroxy-olean- 12 - en- 2 9-oic acid11). (3) is a new compound. Preliminary pharmacological results showed that compounds (1), (3), (4), (5), (7) and (8) have immunosuppressive effects, compounds (1), (4), (5) have antibacterial effects Compound (1) has an antagonistic effect on guinea pig lung LTD4.