大骨节病（KBD）是一种地方性、变形性骨关节病，至今病因和发病机制仍未完全阐明。近年来对KBD发病机制的研究发现，氧化应激、软骨细胞过度凋亡、软骨细胞外基质代谢失衡和促炎症因子等均参与KBD的发生与发展。文中综述了KBD发病机制的重要研究进展。“,”Kaschin-Beck disease (KBD) is an endemic and deforming osteochondropathy, and its pathogen and pathogenesis remain unclear up to now. In recent years, the results in the research of pathogenesis of KBD showed that oxidative stress, excessive chondrocyte apoptosis, imbalance of chondrocyte extracellular matrix metabolism and pro-inflammatory factors were all involved in the occurrence and development of KBD. And this paper summarized the important progress in the pathogenesis of KBD.