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目的应用Meta分析方法定量评价母亲甲硫氨酸合成酶(MTR)基因A2756G和甲硫氨酸合成酶还原酶(MTRR)基因A66G多态性与子代神经管畸形(NTDs)易感性的相关性。方法制定检索策略和文献纳入排除标准,系统检索中国生物医学文献数据库、中文科技期刊数据库、中国期刊全文数据库、万方数据库和PubMed、Webof Science外文数据库中自1990年1月到2011年10月的有关MTR A2756G和MTRR A66G位点多态性与子代NTDs易感性的病例对照研究、学位论文及其引文。采用RevMan5.0软件对各文献进行异质性检验和Meta分析,得到合并后的OR值及其95%CI。结果共有18篇文献纳入Meta分析,MTR A2756G(907例病例和1 978例对照)和MTRR A66G(1 123例病例和1 700例对照)基因多态性的文献各11篇。Meta分析结果显示,母亲MTR基因A2756G位点各遗传模型与子代NTDs易感性之间关联性无统计学意义,而MTRR基因A66G位点GG/AG vsAA、GG vs AA、AG vs AA、GG vs AG/AA和G vs A各遗传模型与子代NTDs易感性之间关联性均有统计学意义,OR值及95%CI分别为1.89(1.28～2.78)、1.68(1.31～2.16)、1.77(1.18～2.66)、1.28(1.06～1.55)和1.35(1.12～1.63)。结论母亲MTRR基因A66G位点多态性是子代NTDs发病的重要危险因素之一。
Objective To quantitatively evaluate the association between maternal methionine synthetase (MTR) gene A75GG and methionine synthase reductase (MTRR) gene A66G polymorphism and susceptibility to offspring neural tube defects (NTDs) using Meta-analysis . Methods To develop a search strategy and document inclusion exclusion criteria, systematically search Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Database, Chinese Journal Full-text Database, Wanfang Database and PubMed, Webof Science foreign language database from January 1990 to October 2011 Case-control studies, dissertations and citations on MTR A2756G and MTRR A66G polymorphisms and offspring NTDs susceptibility. Using RevMan5.0 software heterogeneity test and Meta analysis of the literature, the combined OR value and 95% CI. Results A total of 18 articles were included in each of 11 articles in the Meta-analysis, MTR A2756G (907 cases and 1, 978 controls) and MTRR A66G (1 123 and 1700 controls) gene polymorphisms. The results of Meta analysis showed that there was no significant correlation between MTRR gene A66G locus GG / AG vsAA, GG vs AA, AG vs AA, GG vs The correlation between AG / AA and G vs A genetic models and offspring NTDs susceptibility were statistically significant, OR values and 95% CI were 1.89 (1.28-2.78), 1.68 (1.31-2.16), 1.77 1.18 ~ 2.66), 1.28 (1.06 ~ 1.55) and 1.35 (1.12 ~ 1.63). Conclusion A66G polymorphism of MTRR gene is one of the important risk factors of offspring NTDs.