甲状腺乳头状癌是最常见的甲状腺恶性肿瘤,其与滤泡性肿瘤(包括滤泡性癌和滤泡性腺瘤)的鉴别诊断目前仍基于形态学观察,尚缺乏可靠的非形态学指标。近年来,随着淋巴管内皮特异性标记物的出现,肿瘤淋巴管形成及其在肿瘤转移中的研究逐渐深入。作者对淋巴管内皮特异性标记物、淋巴管生长因子及其在甲状腺分化型肿瘤中的研究进展作一综述。 Papillary thyroid carcinoma is the most common thyroid malignant tumor. The differential diagnosis between follicular tumors (including follicular carcinoma and follicular adenoma) is still based on morphological observation. There is a lack of reliable non-morphological indicators. In recent years, with the appearance of lymphatic endothelial specific markers, lymphangiogenesis and its progress in tumor metastasis are gradually deepened. The authors reviewed the progress of lymphatic endothelial specific markers, lymphangiogenesis factors and their clinical significance in thyroid differentiated tumors.