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目的初步建立长沙地区健康妊娠期妇女肾功能参考区间,为指导长沙地区孕妇临床观察提供理论依据。方法采用贝克曼库尔特AU5800全自动生化分析仪检测长沙地区2 083例健康孕妇血清肾功能三项(尿素、肌酐、尿酸),使用SPSS19.0统计软件进行分析,得出其参考区间,并比较不同年龄和不同孕周期组之间的差异。结果健康孕妇的尿素(1.79~5.31 vs 2.90~7.14)和肌酐(42.8~81.9 vs 53.0~132.6)的参考区间均低于健康成人,而尿酸(159.3~433.7 vs142.0~416.0)则高于健康成人。健康妊娠期妇女的尿素和尿酸参考区间与年龄无关,而肌酐随着年龄的增长参考区间数值稍降低;不同孕周期的健康孕妇肾功能差异有统计学意义,尿素和肌酐的参考区间数值变化趋势相同(孕晚期>孕早期>孕中期),而尿酸的变化趋势不同(孕晚期>孕中期>孕早期)。结论应建立符合健康妊娠期妇女不同年龄和不同孕周期的肾功能参考区间,对判断孕妇肾功能改变有重大意义。
Objective To establish a reference interval of renal function in healthy pregnant women in Changsha area and provide a theoretical basis for clinical observation of pregnant women in Changsha area. Methods The Beckman Coulter AU5800 automatic biochemical analyzer was used to detect serum renal function (urea, creatinine, uric acid) in 2 083 healthy pregnant women in Changsha. The data were analyzed by using SPSS19.0 statistical software to obtain the reference interval Differences between groups of different age and gestational age were compared. Results The reference intervals of urea (1.79 ~ 5.31 vs 2.90 ~ 7.14) and creatinine (42.8 ~ 81.9 vs 53.0 ~ 132.6) in healthy pregnant women were lower than those in healthy adults, while the uric acid (159.3 ~ 433.7 vs142.0 ~ 416.0) adult. The reference interval of urea and uric acid in healthy pregnant women has nothing to do with age, but the reference interval of creatinine slightly decreases with age. The difference of renal function in healthy pregnant women of different gestational periods is statistically significant, the trend of change of reference interval of urea and creatinine The same (third trimester> first trimester> second trimester), while uric acid showed different trends (third trimester> second trimester> first trimester). Conclusions A reference interval of renal function that accords with healthy pregnant women of different ages and different gestational periods should be established, which is of great significance for judging changes of renal function in pregnant women.