目的　分析家兔固定时间对热原试验结果的影响。方法　按照《中国生物制品规程》2 0 0 0年版的生物制品热原质试验规程进行。结果　按规定测量 6次体温 ,制品均合格 ,而延长测温 2h ,变为不合格和复试的制品批次占总试验批次的 30 8% ,且存在显著性差异 (P <0 0 5 )。结论　家兔固定时间过长可致热原试验结果出现误差 Objective To analyze the effect of fixation time on the pyrogen test results in rabbits. Methods According to “China Biological Products Regulations” 2000 version of the hot products of biological products test procedures. Results The body temperature was measured 6 times according to the regulations, and the products were all qualified. However, the prolonged measurement of temperature for 2h resulted in 30.8% of batches of products failed and retest, and there was a significant difference (P <0 05) . Conclusion The fixed time of rabbits can cause errors in the results of pyrogen test