测定B细胞分泌功能对了解糖尿病的发生、发展 ,预测糖尿病的预后非常必要 ,其方法主要分为检测葡萄糖刺激、非糖物质刺激的胰岛素分泌以及B细胞分泌其他物质的功能。葡萄糖刺激的方法有高葡萄糖钳夹技术、口服及静脉葡萄糖耐量试验。非糖物质刺激的方法有精氨酸、胰升糖素、甲苯磺丁脲刺激试验。另外 ,可用于检测的B细胞分泌的其他物质有胰岛素原、C肽、胰淀粉样多肽。在评价B细胞功能的同时需进行胰岛素敏感性参数校正 ,以获得较高的精确性 Determination of B cell secretion to understand the occurrence and development of diabetes, the prognosis of diabetes is very necessary, the method is mainly divided into the detection of glucose stimulation, non-sugar-stimulated insulin secretion and B cell secretion of other substances. Glucose-stimulated methods are high glucose clamp techniques, oral and intravenous glucose tolerance tests. Non-sugar substances stimulate the arginine, glucagon, tolbutamide stimulation test. In addition, other substances secreted by B cells that can be used for detection are proinsulin, C-peptide, and amylin. In assessing B-cell function, insulin sensitivity parameters need to be corrected for higher accuracy