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目的:检测P物质(SP)、血管活性肠肽(VIP)在口腔扁平苔藓(OLP)血清中的表达,并探讨SP、VIP与OLP的关系。方法:采用酶联免疫吸附法(ELISA)检测40例OLP和正常人血清中SP、VIP的含量。结果:SP在OLP患者血清中的含量高于正常人血清中含量(P<0.05),VIP在OLP患者血清中的含量与正常人血清中的含量无差异(P>0.05)。结论:SP在OLP的发生发展中可能参与了淋巴细胞的浸润及增殖,并参与了OLP慢性炎症机制。
Objective: To detect the expression of substance P (SP) and vasoactive intestinal peptide (VIP) in the serum of oral lichen planus (OLP) and to explore the relationship between SP, VIP and OLP. Methods: Serum levels of SP and VIP in 40 cases of OLP and normal persons were detected by enzyme-linked immunosorbent assay (ELISA). Results: The content of SP in the serum of OLP patients was higher than that in normal people (P <0.05). There was no difference in serum levels of VIP between the OLP patients and controls (P> 0.05). Conclusion: SP may be involved in the infiltration and proliferation of lymphocytes in the development of OLP, and participate in the mechanism of OLP chronic inflammation.