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采用上下移动法,醋酸扭体法、热板法、福尔马林致痛试验对臭灵丹水提取物的急性毒性及镇痛作用进行了研究。结果显示:臭灵丹水提取物LD50(腹腔注射)为1.19g/kg;臭灵丹水提取物明显抑制醋酸所致的小鼠扭体数,显著减少福尔马林致痛试验后期小鼠舔足行为;而对热板法所致疼痛无明显作用。表明臭灵丹水提取物具有一定的外周镇痛作用。
The acute toxicity and analgesic effects of the water extract of miracida were studied by up and down movement method, acetic acid writhing method, hot plate method and formalin induced pain test. The results showed that the LD50 (intraperitoneal injection) of the water extract of Ammonanthus danxifolia was 1.19g/kg; the water extract of Ammonanthus odoratum significantly inhibited the number of writhing of mice caused by acetic acid, and significantly reduced the mouse during the late period of formalin induced pain test. Cowardly behavior; and no significant effect on the pain caused by the hot plate method. Shows that the Danling Danshui extract has a certain peripheral analgesic effect.