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目的:对86例组织细胞性坏死性淋巴结炎进行回顾性分析,探讨该病的诊断和鉴别诊断依据。方法:对86例从病理上确诊为组织细胞性坏死性淋巴结炎的病例,结合临床特点和免疫组化进行分析与观察。结果:78例坏死从皮质区开始呈三角形向下延伸;坏死灶内明显的核碎片及淋巴细胞凋亡见于所有的病例;淋巴结内出现片状或灶状形态多样的组织细胞增生。40例病灶区免疫组化标记LCA、Mac387及CD3均为阳性表达。结论:本病病理形态以淋巴结灶性坏死及组织细胞反应为特征,免疫组化标记Mac387及CD3阳性表达,对本病诊断有很重要的价值。
OBJECTIVE: To retrospectively analyze 86 cases of histiocytic necrotizing lymphadenitis, and to investigate the diagnosis and differential diagnosis of this disease. Methods: Totally 86 cases were diagnosed as osteocystic necrotizing lymphadenitis by pathology. The clinical features and immunohistochemistry were analyzed and observed. Results: Seventy-eight cases of necrosis extended from the cortical area to a triangle. The obvious nuclear fragments and lymphocyte apoptosis in the necrotic lesions were found in all the cases. There were flaky or focal tissue-like tissue hyperplasia in the lymph nodes. Immunohistochemical staining of LCA, Mac387 and CD3 in 40 lesions were positive. Conclusion: The pathological features of this disease are characterized by focal necrosis of lymph nodes and histiocytic reaction. The expression of immunohistochemical markers Mac387 and CD3 are of great value in the diagnosis of this disease.