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目的观察p16在不同的宫颈病变中的表达情况。方法采用免疫组织化学S-P检测法,检测宫颈组织石蜡包埋标本108例(LCIN22例、HCIN22例和SC64例)p16的表达状况。结果 p16的表达强度从LCIN组、HCIN组到SC组逐渐增强,呈正相关(Gamma=0.568,P<0.01)。在SC组中,在SC组中,p16蛋白的阳性表达与组织学分级相关,与临床分期和患者的年龄无相关性。结论随着病变级别的升高(从LCIN、HCIN到SC),p16的表达趋势是逐渐升高的,提示它可能在宫颈癌的发展的过程中起重要作用,可作为预测CIN转归的指标。p16可能是宫颈癌早期诊断的重要标记物;p16的表达与宫颈鳞癌的分化有关,提示p16可能参与了宫颈鳞癌的分化过程。
Objective To observe the expression of p16 in different cervical lesions. Methods The immunohistochemical S-P method was used to detect the expression of p16 in 108 cases of cervical tissue specimens (22 cases of LCIN, 22 cases of HCIN and SC64 cases). Results The expression level of p16 increased gradually from LCIN group to HCIN group to SC group (Gamma = 0.568, P <0.01). In SC group, in SC group, the positive expression of p16 protein was correlated with histological grade, but not with clinical stage and patient’s age. Conclusions The expression of p16 is gradually increased with the increase of pathological grade (from LCIN, HCIN to SC), suggesting that it may play an important role in the development of cervical cancer and may be used as an index to predict the outcome of CIN . p16 may be an important marker of early diagnosis of cervical cancer; p16 expression and cervical squamous cell carcinoma differentiation, suggesting that p16 may be involved in the differentiation of cervical squamous cell carcinoma.