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AIM:To investigate the correlation of toll-like receptor 4(TLR4)gene Asp299Gly and Thr399Ile polymorphisms and acute pancreatitis(AP)risk and severity.METHODS:To get a more precise estimation of the relationship,a comprehensive search was performed to examine all the eligible studies of TLR4 Asp299Gly and Thr399Ile polymorphisms and AP risk.The odds ratios with 95%confidence intervals were used to assess the strength of the association.Publication bias was analyzed by Begg’s funnel plots.RESULTS:In total,six studies with 1255 cases and998 controls were included in this meta-analysis.Totally,no significant associations were found betweenTLR4 Asp299Gly or Thr399Ile polymorphisms and AP risk using five models with high homogeneity(P>0.05).Furthermore,stratification analysis by ethnicity or assay also found no significant association in these two polymorphisms(P>0.05),and TLR4 Asp299Gly was not associated with AP severity(P>0.05).In addition,no publication bias was found in these studies(P>0.05).CONCLUSION:Our current meta-analysis suggests that TLR4 Asp299Gly and Thr399Ile polymorphisms may not be risk factors to AP susceptibility.
To investigate the correlation of toll-like receptor 4 (TLR4) gene Asp299Gly and Thr399Ile polymorphisms and acute pancreatitis (AP) risk and severity. METHODS: To get a more precise estimation of the relationship, a comprehensive search was performed to examine all the eligible studies of TLR4 Asp299Gly and Thr399Ile polymorphisms and AP risk. odds ratios with 95% confidence intervals were used to assess the strength of the association. Publications bias was analyzed by Begg’s funnel plots .RESULTS: In total, six studies with 1255 cases and 998 controls were included in this meta-analysis. Totally, no significant associations were found betweenTLR4Asp299Gly or Thr399Ile polymorphisms and AP risk using five models with high homogeneity (P> 0.05) .Furthermore, stratification analysis by ethnicity or assay also found no significant association in these two polymorphisms (P> 0.05), and TLR4 Asp299Gly was not associated with AP severity (P> 0.05). Addition, no publication bias was found in these studies (P> 0.05) .CONCLUSION: Our current meta-analysis suggests that TLR4 Asp299Gly and Thr399Ile polymorphisms may not be risk factors to AP susceptibility.