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目的:研究阿仑膦酸钠对绝经后骨质疏松症老年女性血清AKP、骨特异性碱性磷酸酶(BAP)的影响,并进一步探讨两者的相关性。方法:回顾性分析286例绝经后骨质疏松症老年女性患者,根据治疗前患者AKP值分为AKP正常组(245例)和非肝胆管源性AKP升高组(41例),考察两组患者阿仑膦酸钠治疗前后AKP与BAP水平,并分析BAP与AKP、AKP变化(ΔAKP)与BAP变化(ΔBAP)在治疗前后的相关性。结果:AKP与BAP随患者年龄增大呈升高趋势。治疗前AKP升高组的BAP水平高于AKP正常组(P<0.05),BAP与AKP呈显著正相关(P<0.05);治疗后两组AKP与BAP水平均降低,BAP与AKP呈显著正相关(P<0.05);治疗后ΔAKP与ΔBAP亦呈显著正相关(P<0.05)。结论:AKP与BAP水平随年龄呈升高趋势,非肝胆管源性AKP升高的绝经后骨质疏松症老年女性患者,阿仑膦酸钠治疗可显著降低AKP水平,其水平的降低与BAP水平的下降呈高度正相关。
Objective: To study the effect of alendronate on serum AKP and bone specific alkaline phosphatase (BAP) in elderly women with postmenopausal osteoporosis and to explore the relationship between them. Methods: A retrospective analysis of 286 elderly women with postmenopausal osteoporosis patients was divided into two groups according to AKP value: AKP normal group (245 cases) and non-hepatobiliary origin AKP elevated group (41 cases) The levels of AKP and BAP in patients before and after treatment with alendronate were analyzed. The changes of BAP and AKP, AKP changes (ΔAKP) and BAP changes (ΔBAP) before and after treatment were analyzed. Results: AKP and BAP increased with age. The level of BAP in AKP elevated group before treatment was higher than that in normal AKP group (P <0.05), and BAP was positively correlated with AKP (P <0.05). AKP and BAP levels were decreased in both groups after treatment, while BAP and AKP were significantly positive (P <0.05). There was also a significant positive correlation between ΔAKP and ΔBAP after treatment (P <0.05). Conclusions: The AKP and BAP levels increase with age. In elderly women with postmenopausal osteoporosis without elevated biliary AKP, alendronate treatment can significantly reduce the level of AKP, the level of AKP and BAP The level of decline was highly positively correlated.