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用地塞米松（Ｄｅｘ）和ＲＵ４８６分别或联合与鸡淋巴细胞、ＣｏｎＡ一起培养，检测了淋巴细胞掺入３Ｈ－胸苷（３Ｈ－ＴｄＲ）量的变化。１０－５和１０－６ｍｏｌ／ＬＲＵ４８６可抑制淋巴细胞掺入３Ｈ－ＴｄＲ（Ｐ＜０．０１），而１０－７ｍｏｌ／Ｌ则无明显影响（Ｐ＞０．０５）；１０－５、１０－６和１０－７ｍｏｌ／ＬＤｅｘ对淋巴细胞掺入３Ｈ－ＴｄＲ有明显的抑制作用（Ｐ＜０．０１）；１０－５ｍｏｌ／ＬＲＵ４８６对Ｄｅｘ（１０－５～１０－７ｍｏｌ／Ｌ）的淋巴细胞掺入３Ｈ－ＴｄＲ抑制无明显逆转作用（Ｐ＞０．０５），而１０－７ｍｏｌ／ＬＲＵ４８６对Ｄｅｘ（１０－５～１０－７ｍｏｌ／Ｌ）的淋巴细胞掺入３Ｈ－ＴｄＲ抑制则有明显逆转作用（Ｐ＜０．０１）。将Ｄｅｘ、ＲＵ４８６分别与被ＣｏｎＡ活化２４ｈ的鸡淋巴细胞一起培养，１０－５ｍｏｌ／ＬＲＵ４８６可抑制淋巴细胞掺入３Ｈ－ＴｄＲ（Ｐ＜０．０１），而１０－６～１０－７ｍｏｌ／Ｌ则无影响（Ｐ＞０．０５）；１０－５～１０－６ｍｏｌ／ＬＤｅｘ可抑制淋巴细胞掺入３Ｈ－ＴｄＲ（Ｐ＜０．０５），１０－７无影响（Ｐ＞０．０５）。结果表明，高浓度的ＲＵ４８６（１０－５ｍｏｌ／Ｌ）可阻断糖皮质激素受体（ＧＲ?
The dexamethasone (Dex) and RU486 were incubated with chicken lymphocytes and Con A separately or in combination with lymphocytes to measure the incorporation of 3H-thymidine (3H-TdR) into lymphocytes. 10-5 and 10-6mol / LRU486 could inhibit the incorporation of 3H-TdR into lymphocytes (P <0.01), while the effect of 10-7mol / L had no significant effect (P> 0.05) 6 and 10-7mol / LDex significantly inhibited the incorporation of 3H-TdR into lymphocytes (P <0.01). The inhibitory effect of 10-5mol / L LR48 on Dex (10-5-10-7mol / L) There was no obvious reversal effect of 3H-TdR inhibition (P> 0.05), while 10-7mol / LRU486 inhibited the 3H-TdR incorporation in Dex (10-5 ~ 10-7mol / L) (P <0.01). Dex and RU486 cells were incubated with lymphocytes of lymphocytes activated by ConA for 24h respectively. 3H-TdR incorporation was inhibited by 10-5mol / LRU486 (P <0.01), while 10-6-10-7mol / L No effect (P> 0.05); 10-5 ~ 10-6mol / LDex inhibited lymphocyte incorporation of 3H-TdR (P <0.05), 10-7 no effect (P> 0.05). The results show that high concentration of RU486 (10-5mol / L) can block glucocorticoid receptor (GR?