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目的 :观察α1受体阻滞剂联合抗生素治疗慢性前列腺炎 (CP)的疗效 ,初步探讨α1受体阻滞剂缓解CP症状的机制。 方法 :将 80例CP患者随机分成 2组 ,每组 4 0例 :治疗组口服特拉唑嗪 2mg及左旋氧氟沙星 0 .2g ,每日 2次 ;对照组仅口服左旋氧氟沙星 0 .2g ,每日 2次。治疗 6周 ,观察治疗前后慢性前列腺炎症状指数评分 (NIH CPSI)、前列腺按摩液常规及尿流动力学指标的变化。 结果 :治疗组NIH CPSI由治疗前 (31.8± 7.4 )分降至 (15 .5± 6 .6 )分 ,对照组NIH CPSI由治疗前 (30 .9± 7.1)分降至 (2 1.4± 6 .2 )分 ,治疗组改善程度较对照组更为显著 (P <0 .0 5 )。治疗组治疗前后最大尿流率 (MFR)分别为 (16 .5± 6 .3)ml/s和 (2 0 .4± 4 .6 )ml/s,两者差异有显著性 (P <0 .0 5 ) ;治疗组治疗前后最大尿道压 (MUP)分别为 (92 .5± 15 .3)cmH2 O和 (72 .5± 13.4 )cmH2 O ,两者差异有显著性 (P <0 .0 5 ) ;对照组治疗前后MFR分别为 (16 .1± 5 .8)ml/s和 (17.3± 6 .8)ml/s,MUP分别为 (93.2± 14 .8)cmH2 O和 (91.7± 13.6 )cmH2 O ,治疗前后差异均无显著性 (P >0 .0 5 )。 结论 :α1受体阻滞剂可降低尿道压力 ,缓解前列腺内尿液返流 ,与抗生素合用可提高疗效。
OBJECTIVE: To observe the curative effect of α1 receptor blocker and antibiotics on chronic prostatitis (CP) and to explore the mechanism of α1 blockers in relieving symptoms of CP. Methods: Eighty CP patients were randomly divided into two groups (40 cases in each group): The treatment group was given oral terazosin 2mg and levofloxacin 0.2g twice a day, while the control group was given only levofloxacin 0 .2g, 2 times a day. After 6 weeks of treatment, the changes of NIH CPSI, routine prostate massage and urodynamic indexes before and after treatment were observed. Results: The NIH CPSI in the treatment group decreased from (31.8 ± 7.4) points to (15.5 ± 6.6) points before treatment and that in the control group decreased from (30.9 ± 7.1) points to (2 ± 1.4 ± 6) .2) points, the treatment group improved more significantly than the control group (P <0. 05). The maximum flow rate (MFR) before and after treatment in the treatment group was (16.5 ± 6.3) ml / s and (20.4 ± 4.6) ml / s respectively, with significant difference between the two groups .05). The maximum urethral pressure (MUP) before and after treatment in the treatment group was (92.5 ± 15.3) cmH 2 O and (72.5 ± 13.4) cmH 2 O, respectively, with significant difference between the two groups (P <0. The MFR of the control group before and after treatment were (16.1 ± 5.1) ml / s and (17.3 ± 6.8) ml / s respectively, and the MUP values were (93.2 ± 14.8) cmH2O and ± 13.6 cmH 2 O, there was no significant difference between before and after treatment (P> 0.05). Conclusion: α1 blockers can reduce the pressure of the urethra and relieve the reflux of urine in the prostate. Combined with antibiotics can improve the curative effect.