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目的:探讨门冬胰岛素联合二甲双胍对妊娠期糖尿病患者母婴结局的影响。方法:选取兴宁鸿惠医院2015年3月至2016年11月收治的妊娠期糖尿病患者80例,随机分为两组,每组40例。对照组采用门冬胰岛素治疗,观察组在对照组基础上加用二甲双胍治疗。比较两组血糖水平、孕妇和新生儿情况。结果:对照组孕妇剖宫产、早产、羊水过多以及妊娠期高血压发生率明显高于观察组,差异具有统计学意义(P<0.05);对照组新生儿黄疸和巨大儿发生率明显高于观察组,差异具有统计学意义(P<0.05)。结论:门冬胰岛素联合二甲双胍能有效降低妊娠期糖尿病患者血糖,改善母婴结局,保证母婴健康,具有较高的临床应用价值。
Objective: To investigate the effect of aspart insulin plus metformin on maternal and infant outcomes in gestational diabetes mellitus. Methods: 80 cases of gestational diabetes mellitus admitted from March 2015 to November 2016 in Xingning Honghui Hospital were randomly divided into two groups (n = 40 in each group). The control group was treated with insulin aspart and the observation group was treated with metformin on the basis of the control group. Compare the two groups of blood glucose levels, pregnant women and newborns. Results: The incidence of cesarean section, premature labor, polyhydramnios and gestational hypertension in control group were significantly higher than those in observation group (P <0.05). The incidence of neonatal jaundice and macrosomia in control group was significantly higher In the observation group, the difference was statistically significant (P <0.05). CONCLUSION: Aspart insulin combined with metformin can effectively reduce the blood sugar in gestational diabetes mellitus patients, improve maternal and infant outcomes and ensure the health of maternal and infant, which has a high clinical value.