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用双抗体夹心免疫放射方法和放免法分别测定了 45例妊高征孕妇和 15例正常孕妇血浆中血小板颗粒膜蛋白140 (GMP140 )和血栓素 B2 (TXB2 )的浓度。结果显示 :妊高征患者血浆中 GMP140、TXB2 水平较正常孕妇明显升高 ,妊高征患者病情越重 ,升高越明显。重度妊高征母血 GMP140、TXB2 与新生儿体重明显相关。提示 :妊高征患者体内血小板高度激活 ,血小板活化与妊高征病情的严重程度有一定关系。
The concentrations of platelet granule membrane protein 140 (GMP140) and thromboxane B2 (TXB2) in 45 PIH pregnant women and 15 normal pregnant women were measured by sandwich ELISA and radioimmunoassay. The results showed that the plasma levels of GMP140 and TXB2 in patients with PIH were significantly higher than those in normal pregnant women. The patients with PIH were more severe and the more obvious the increase was. Severe pregnancy-induced hypertension maternal GMP140, TXB2 significantly correlated with neonatal body weight. Tip: PIH patients in vivo platelet activation, platelet activation and the severity of pregnancy-induced hypertension have a certain relationship.