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Down综合征(DS)患者发生急性白血病凤险增高这一实例提供了良好的生物学材料。50年前首先报道DS与白血病有关联,近几年对这两种病的认识已取得突破性进展。DS是一种最常见的染色体病,白血病是一种最常见的儿童期恶性肿瘤,从逻辑上看偶然出现同时患两种病的儿童是可能的,但这两种病之间的关联远远大于从机率推测的频率,而DS患儿发生其它肿瘤机率不高于推测频率。各种研究都提示DS患者发生白血
The increase in the risk of acute leukemia in patients with Down syndrome (DS) provides a good biological material. 50 years ago, DS was first reported to be associated with leukemia, and in recent years, there has been a breakthrough in understanding these two diseases. DS is one of the most common chromosomal diseases. Leukemia is the most common form of malignancy in childhood. Logically, it is possible to have children who accidentally appear to have both types of diseases. However, these two diseases are far more related. In terms of the frequency of probability estimates, the incidence of other tumors in children with DS was not higher than the estimated frequency. Various studies have suggested that white blood occurs in DS patients