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目的分析系统性红斑狼疮(SLE)并发结核菌感染的临床特点。方法分析我院自1991年1月至2004年1月共收治的426例SLE住院患者。结果426例SLE患者中18例伴有结核,患病率为4.2%,死亡7,例病死率为39%。明显高于普通人群。其中肺结核12,例结核性脑膜炎例淋3,巴结核3例。18例做结核菌素试验纯蛋白衍生物(PPD)强阳性2例(12.5%),阴性16例(87.5%),结核菌素试验PPD阴性率明显高于正常人群。15/18(83%)患者在应用免疫抑制剂6个月～3年内患结核。结论SLE患者由于长期服用免疫抑制剂,易发生结核菌感染且临床表现不典型。其患病率及病死率均明显高于普通人群,因此对结核菌感染的早期诊治对降低病死率十分重要。
Objective To analyze the clinical characteristics of systemic lupus erythematosus (SLE) complicated by mycobacterium tuberculosis infection. Methods Analysis of 426 hospitalized patients with SLE admitted to our hospital from January 1991 to January 2004. Results Among 426 SLE patients, 18 cases were associated with tuberculosis, with a prevalence of 4.2%, death of 7, and case fatality rate of 39%. Obviously higher than the general population. Including tuberculosis 12, cases of tuberculous meningitis leaching 3, Pakistan 3 cases of tuberculosis. Two cases (12.5%) and 16 cases (87.5%) were positive in 18 cases of tuberculin test. The negative rate of PPD in tuberculin test was significantly higher than that in normal people. 15/18 (83%) patients developed tuberculosis within 6 months to 3 years of immunosuppression. Conclusion Patients with SLE are prone to develop mycobacterium tuberculosis due to long-term use of immunosuppressive agents and their clinical manifestations are not typical. The prevalence and mortality were significantly higher than the general population, so early diagnosis and treatment of tuberculosis infection is very important to reduce mortality.