目前治疗皮肤利什曼原虫病仍缺乏一种安全,无毒的有效药物,故需寻找新的治疗该病的化合物。在体外或体内不同模型的试验中,对一些抗寄生虫药物进行了评价,结果发现抗疟药氯喹和阿莫地喹在体外有抗皮肤利什曼原虫的作用。在实验小鼠皮肤感染的试验中,氯喹也显示有效。对东半球的皮肤利什曼病包括 The current treatment of cutaneous Leishmaniasis is still a lack of a safe, non-toxic and effective drugs, it is necessary to find new compounds for the treatment of the disease. In vitro or in vivo experiments with different models, some anti-parasitic drugs were evaluated and found that the antimalarial drugs chloroquine and amodiadequine had an anti-cutaneous Leishmania in vitro effect. Chloroquine also showed efficacy in experiments on skin infections in mice. Skin Leishmaniasis is included in the Eastern Hemisphere