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目的：探讨戈那瑞林与氯米芬对女性内分泌失调不孕症排卵率和受孕率的影响。方法：１２６例女性内分泌失调不孕症（１１０例用氯米芬治疗无效），年龄为（３１±ｓ５）ａ，其中１３例单用戈那瑞林，１１３例戈那瑞林与氯米芬合用，于月经周期ｄ３，氯米芬５０ｍｇ，ｐｏ，ｑｄ，连服５ｄ；在月经周期ｄ１０～１２起，戈那瑞林２５μｇ，ｉｍ，ｑｄ，连用３～５ｄ为一个治疗周期。结果：１２６例共治２７９周期，排卵数２３７次；５８人６２次妊娠，排卵率为８４．９％；受孕成功率为４６％（５８／１２６）。结论：戈那瑞林能治疗单用氯米芬无效的内分泌失调不孕症
Objective: To investigate the effects of gonadorelin and clomiphene on the ovulation rate and pregnancy rate of infertile women with endocrine disorders. Methods: One hundred and sixty-six female infertility patients with endocrine disorders (110 with clomiphene citrate treatment ineffective), with a mean age of (31 ± s5) a, of which 13 were gonadorelin alone and 113 gonadorelin with clomiphene citrate In the menstrual cycle d3, clomiphene citrate 50mg, po, qd, and even served 5d; in the menstrual cycle d10 ~ 12, gonadorelin 25μg, im, qd, once every 3 ~ 5d for a treatment cycle. Results: 126 cases were treated for 279 cycles, the number of ovulation was 237 times; 58 pregnancies were 62 pregnancies, the ovulation rate was 84.9%; the success rate of conception was 46% (58/126). Conclusion: Gonadorelin is able to treat endocrine infertility with clomiphene alone