Objective To examine the association of visceral adiposity as measured by VFA and WC with lipid and glucose metabolic biomarkers in abdominally obese Chinese adults,and to assess whether WC could be an indicator of visceral fat.Methods WC and VFA were measured in 155 overweight and obese adults.A fasting blood sample was collected from participant(n=118) whose VFA ≥100 cm2 for analyses of lipid and glucose profile.The relationship between VFA and WC and biomarkers was investigated.Results WC and VFA were significantly interrelated.The coincidence rate of abdominal obesity determined by Japanese VFA and Chinese WC criteria increased across age quartiles in women from 51.7% to 96.2%.A large WC was associated significantly with low HDL-cholesterol concentration(P<0.01) and the association was weakened by additional control of VFA.WC and VFA were positively associated with glucose,hemoglobin A1c and insulin concentrations(P<0.05 except for the association of VFA with insulin:P<0.01),and all the associations were not significant by additional control of either WC or VFA.As WC quartiles increased,significant stepwise increments in triglyceride,glucose,hemoglobin A1c and insulin and descent in HDL-cholesterol were observed.However,triglyceride and HDL-cholesterol were not significantly different when compared across VFA quartiles.Conclusion Higher visceral fat was associated with an adverse lipid and glucose profile.WC can be a moderate predictor for visceral fat and provides a feasible measurement to estimate glucose metabolic risks.Further studies are warranted to establish age-specific WC cutoffs. Objective To examine the association of visceral adiposity as measured by VFA and WC with lipid and glucose metabolic biomarkers in abdominally obese Chinese adults, and to assess whether WC could be an indicator of visceral fat. Methods WC and VFA were measured in 155 overweight and obese Adults. A fasting blood sample was collected from participant (n = 118) whose VFA ≥100 cm2 for analyses of lipid and glucose profile. the relationship between VFA and WC and biomarkers was investigated. Results WC and VFA were significantly interrelated. The coincidence rate of large obesity determined by Japanese VFA and Chinese WC criteria increased across age quartiles in women from 51.7% to 96.2%. A large WC was associated significantly with low HDL-cholesterol concentration (P <0.01) and the association was weakened by additional control of VFA.WC and VFA were positively associated with glucose, hemoglobin A1c and insulin concentrations (P <0.05 except for the association of VFA with insulin: P <0.01), and all the associations were not significant by additional control of either WC or VFA.As WC quartiles increased, significant stepwise increments in triglyceride, glucose, hemoglobin A1c and insulin and descent in HDL-cholesterol were observed. Despite, triglyceride and HDL-cholesterol were not significantly different when compared across VFA quartiles. Conclusions Higher visceral fat was associated with an adverse lipid and glucose profile. WC can be a moderate predictor for visceral fat and provide a feasible measurement to estimate glucose metabolic risks. Future studies are warranted to establish age- specific WC cutoffs.