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滔罗定(Taurolidine)是1种广谱抗菌药,临床上可用于多种感染疾病的治疗。近年来大量研究表明Taurolidine具有良好的抗肿瘤活性。Taurolidine的抗肿瘤机制尚未完全明确,已有的研究证明其通过促进细胞凋亡、抑制血管生成、减少肿瘤黏附、下调促炎细胞因子释放水平和刺激外科手术后抗肿瘤免疫调节等多种途径发挥抗肿瘤作用。本文综述Taurolidine在抗肿瘤方面的研究进展。
Taurolidine is a broad spectrum antimicrobial that is clinically useful in the treatment of a variety of infectious diseases. In recent years, a large number of studies have shown that Taurolidine has good anti-tumor activity. The antitumor mechanism of Taurolidine has not yet been completely elucidated. It has been reported that Taurolidine exerts its antitumor effect in many ways, such as promoting apoptosis, inhibiting angiogenesis, reducing tumor adhesion, lowering the level of proinflammatory cytokines and stimulating the anti-tumor immune regulation after surgery Antitumor effect. This article reviews the progress of Taurolidine in anti-tumor research.