粘附分子 (adhesion molecules,AMs)是在细胞表面表达具有介导细胞间或细胞与细胞外基质相互作用的糖蛋白。 E-选择素 (E- selectin)是粘附分子中选择素家族成员之一。它是介导白细胞与内皮细胞粘附起始阶段的重要因子 [1 ] 。近年不少研究表明 :AMs在糖尿病慢性并发症的发生、 Adhesion molecules (AMs) are glycoproteins expressed on the cell surface that mediate intercellular or cell interactions with the extracellular matrix. E-selectin is one member of the selectin family of adhesion molecules. It is an important factor mediating the initial phase of leukocyte-endothelial cell adhesion [1]. In recent years, many studies have shown that: AMs in the occurrence of chronic complications of diabetes,