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目的探讨我省麻疹强化免疫后发生的疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)的病例特征,评估麻疹减毒活疫苗(Measles Attenuated Live Vaccine,MV)的安全性,为AEFI监测、诊断和处理提供科学依据。方法通过书面报告及全国AEFI监测网络报告系统,收集所有报告个案数据,采用描述性方法对相关指标进行分析。结果青海省麻疹疫苗强化后共报告AEFI病例65例,报告发生率为42.02/100万剂。大部分病例报告来自西宁,占58.46%;临床表现以发热伴全身皮疹、紫癜等过敏性反应为主,占56.92%。所有病例预后良好,无严重病例及死亡病例。结论麻疹疫苗的安全性好,预防接种服务质量良好。本省AEFI监测报告病例少,灵敏性较低。
Objective To investigate the case characteristics of suspected immunization against measles immunization (AEFI) after measles immunization in our province and evaluate the safety of Measles Attenuated Live Vaccine (MV) for the surveillance and diagnosis of AEFI And provide a scientific basis for handling. Methods Through the written report and the national AEFI monitoring network reporting system, all reported case data were collected and descriptive methods were used to analyze the relevant indicators. Results A total of 65 AEFI cases were reported in Qinghai Province after the measles vaccine was strengthened. The reported incidence rate was 42.02 / 1 million doses. Most cases reported from Xining, accounting for 58.46%; clinical manifestations of fever with systemic rash, purpura and other allergic reactions, accounting for 56.92%. The prognosis of all cases was good, no serious cases and deaths. Conclusion The safety of measles vaccine is good and the vaccination service is of good quality. The province AEFI monitoring report less cases, less sensitive.