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目的：探索细胞周期抑制蛋白p16、p27异常表达与胃癌生物学行为的关系。方法：免疫组织化学方法（S－P法）检测胃癌组织中p16、p27的表达，结合临床病理资料和随访资料进行回顾性研究，并作出评价。结果：p16表达降低与胃癌分期增加、淋巴结转移及不良预后显著相关。p27表达降低与淋巴结转移、浆膜浸润、晚期胃癌、弥漫型胃癌及不良预后显著相关。结论：p16、p27异常表达与胃癌不良的生物学行为及预后有关，可作为预后指标，有利于个体化治疗及提高胃癌的疗效
Objective: To explore the relationship between abnormal expression of cell cycle arrest protein p16, p27 and biological behavior of gastric cancer. Methods: Immunohistochemical method (S-P method) was used to detect the expression of p16 and p27 in gastric cancer tissues. Retrospective study was performed according to clinical pathological data and follow-up data and evaluated. RESULTS: The decreased expression of p16 was significantly associated with increased staging of gastric cancer, lymph node metastasis, and poor prognosis. The decreased expression of p27 was significantly associated with lymph node metastasis, serosal infiltration, advanced gastric cancer, diffuse gastric cancer, and poor prognosis. Conclusion: Abnormal expression of p16 and p27 is associated with poor biological behaviors and prognosis of gastric cancer. It can be used as a prognostic indicator to help individualized treatment and improve the efficacy of gastric cancer.