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作者对使用环孢素A治疗活动性克隆病进行临床试验,并评价此药的疗效。方法:7例经放射学、内镜和组织学检查确诊的活动性克隆病人用环孢素A治疗,年龄17～39岁(平均27岁),6例男性,1例女性。6例侵及回结肠,1例仅结肠受累。平均病程8±7年。5例因克隆病曾接受一次以上的手木治疗。2例并发肠瘘。环孢素A治疗期间停用类固醇和水杨酸偶氮磺胺吡啶,但晚间继续给要素饮食800～1200千卡/日。口服环孢素A首剂8mg/kg,其后每2周调整剂量以维持血浆浓度在200ng/ml左右。用高效液相色谱法测定血浆环孢素A浓度。4例服16周,服23周和30周者各1例。每2周评价临床症
The authors conducted a clinical trial of cyclosporin for the treatment of active Crohn’s disease and evaluated the efficacy of the drug. Methods: Seven patients with active colon disease diagnosed by radiology, endoscopy and histology were treated with cyclosporine A, aged 17-39 years (mean 27 years), 6 males and 1 females. 6 cases of invasion and back to the colon, 1 case of colon involvement. The average duration of 8 ± 7 years. Five cases of Crohn’s disease had received more than one hand wood treatment. 2 cases of intestinal fistula. Steroid and salicylazosulfapyridine were discontinued during cyclosporine A treatment, but 800 to 1200 kcal / day was continued for the evening diet. Oral cyclosporine A first dose of 8mg / kg, then adjust the dose every 2 weeks to maintain the plasma concentration of about 200ng / ml. Plasma concentrations of cyclosporin A were determined by high performance liquid chromatography. 4 cases for 16 weeks, 23 cases and 30 weeks for each one case. Clinical symptoms were evaluated every 2 weeks