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本研究旨在确定通过α干扰素(IFN-α)治疗是否可影响α肿瘤坏死因子(TNF-α)及白细胞介素1β(IL-1β)的产生以及这两种因子是否有助于清除HBV.试验对象为血清HBsAg、HBeAg及HBVDNA阳性至少1年、而用IFN-α治疗的7例男性患者,年龄为28～52岁.其中慢性活动性肝炎(伴有肝硬化)2例,慢性持续性肝炎5例(有1例肝硬化).治疗方法为类成淋巴细胞干扰素10~7U/天,共5天,然后每周3次,,3或6个月,并根据副反应调整剂量.治疗期间每月随访1次,持续18个月以
The aim of this study was to determine whether IFN-α treatment can affect the production of TNF-α and IL-1β and whether these two factors contribute to the clearance of HBV The subjects were positive for serum HBsAg, HBeAg and HBVDNA for at least 1 year, whereas 7 male patients treated with IFN-α, aged 28 to 52 years, of whom 2 chronic active hepatitis with cirrhosis, chronic persistent 5 cases of hepatitis (1 case of cirrhosis) .Treatment method for lymphoblastoid interferon 10 ~ 7U / day for 5 days, then 3 times a week, 3 or 6 months, and adjust the dose according to side effects During the treatment period, the patients were followed up once every month for 18 months