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目的探讨链霉蛋白酶在胃镜检查中的应用效果。方法将接受胃镜检查的270例患者按随机数字表法分为2组:试验组129例,检查前30min口服链霉蛋白酶和碳酸氢钠的混合液50mL,并于检查前10min口服盐酸利多卡因胶浆10mL;对照组141例,检查前10min口服盐酸利多卡因胶浆10mL。胃镜检查时分别对胃底、胃体上部、胃体下部、胃窦的黏膜清晰度进行评分,比较2组萎缩性胃炎及伴有肠上皮化生检出率。结果试验组胃底、胃体上部、胃体下部、胃窦黏膜以及总黏膜清晰度评分分别为(1.81±0.88)、(1.53±0.72)、(1.29±0.50)、(1.47±0.71)、(6.09±1.87)分,对照组分别为(2.48±0.67)、(2.37±0.80)、(2.31±0.78)、(2.12±0.83)、(9.23±2.39)分,试验组各部位及总胃黏膜评分均显著低于对照组,差异有统计学意义(P<0.001)。试验组对萎缩性胃炎及伴有肠上皮化生检出率显著高于对照组(17.8%比10.6%,P<0.05)。结论链霉蛋白酶能有效提高胃镜检查时胃黏膜清晰度,有利于胃黏膜微小病变的发现。
Objective To investigate the effect of pronase in gastroscopy. Methods A total of 270 patients undergoing gastroscopy were randomly divided into two groups according to the random number table: 129 in the test group, 50 mL of the mixture of pronase and sodium bicarbonate 30 min before the test, and oral lidocaine hydrochloride 10 min before the test Glue 10mL; control group of 141 patients, check oral 10min before oral lidocaine hydrochloride 10mL. Gastroscopy during gastric fundus, upper gastric body, lower corpus, gastric mucosa sharpness were scored, compared with two groups of atrophic gastritis and intestinal metaplasia with the detection rate. Results The scores of gastric fundus, upper part of gastric body, lower part of gastric body, antral mucosa and total mucosa of test group were (1.81 ± 0.88), (1.53 ± 0.72), (1.29 ± 0.50) and (1.47 ± 0.71) 6.09 ± 1.87), and the control group were (2.48 ± 0.67), (2.37 ± 0.80), (2.31 ± 0.78), (2.12 ± 0.83) and (9.23 ± 2.39) Were significantly lower than the control group, the difference was statistically significant (P <0.001). The detection rate of atrophic gastritis and intestinal metaplasia in the experimental group was significantly higher than that in the control group (17.8% vs. 10.6%, P <0.05). Conclusion Pronase can effectively improve gastroscopy gastroscopy clarity, is conducive to the discovery of gastric mucosal lesions.