【摘 要】
：
目的 研究不同剂量右美托咪定用于颅脑手术患者的临床价值,为优化颅脑手术的麻醉方案提供参考.方法 选取2017年6月至2021年6月陕西省人民医院收治的90例颅脑手术患者为研究对象,按照随机数字表法分为A组、B组和C组,各30例.3组患者均在手术完成前15 min肌内注射右美托咪定,A组剂量为1.0μg/kg,B组为1.5μg/kg,C组为2.0μg/kg.记录3组患者术前(T1)、给药前5 min(T2)、手术结束时(T3)及术后30 min时(T4)血流动力学指标水平,记录3组患者麻醉不良反应发生率.结
【机 构】
：
西安医学院研究生处,陕西西安 710021;陕西省人民医院急诊外科,陕西西安 710068
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目的 研究不同剂量右美托咪定用于颅脑手术患者的临床价值,为优化颅脑手术的麻醉方案提供参考.方法 选取2017年6月至2021年6月陕西省人民医院收治的90例颅脑手术患者为研究对象,按照随机数字表法分为A组、B组和C组,各30例.3组患者均在手术完成前15 min肌内注射右美托咪定,A组剂量为1.0μg/kg,B组为1.5μg/kg,C组为2.0μg/kg.记录3组患者术前(T1)、给药前5 min(T2)、手术结束时(T3)及术后30 min时(T4)血流动力学指标水平,记录3组患者麻醉不良反应发生率.结果 A、C两组患者T1、T2、T3及T4时心率(HR)和平均动脉压(MAP)水平比较,差异均有统计学意义(均P0.05).3组患者心动过缓发生率比较,差异有统计学意义(P<0.05),其中B组患者心动过缓发生率显著低于C组(P<0.05).结论 右美托咪定用于颅脑手术患者麻醉效果可靠,手术结束前采用1.5μg/kg剂量的右美托咪定有助于稳定血流动力学,减轻术后不良反应,值得临床应用.
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